Nanoparticle based drug delivery systems have been rapidly growing and are being applied to various sections of biomedicine. Drug nanocarriers based on dendrimers, liposomes, self-assembling peptides, watersoluble polymers, and block copolymer micelles are the most extensively studied types of drug delivery systems and some of them are being used in clinical therapy.
In particular for cancer therapy, antineoplastic drugs are taking advantage of nanoparticulate drug carriers to improve the cure efficacy. Nanoparticle based drug carriers are capable of improving the therapeutic effectiveness of the drugs by using active targeting for the site-specific delivery, passive targeting mechanisms such as enhanced permeability and retention EPR , de novo synthesis and uptake of low density liposome in cancer cells or by being water-soluble to improve the suboptimal pharmacokinetics in limited water-soluble delivery methods.
Keywords: Drug delivery, encapsulation, tumor targeted delivery, dendrimers, liposome, self-assembling peptides, water-soluble polymers, block copolymer micelles. Abstract: Conventional drug delivery systems contain numerous limitations such as limited targeting, low therapeutic indices, poor water solubility, and the induction of drug resistances. Journal Name: Current Pharmaceutical Design.
Volume 23 , Issue 14 , Colloidal nanocarriers: a review on formulation technology, types and applications toward targeted drug delivery. Tamoxifen-loaded nanostructured lipid carrier as a drug delivery system: characterization, stability assessment and cytotoxicity. Colloids Surf B Biointerfaces. Engineered nanoparticles for drug delivery in cancer therapy. Angew Chem Int Ed. Chemotherapy with anticancer drugs encapsulated in solid lipid nanoparticles.
Adv Drug Deliv Rev. Nanoparticle delivery of cancer drugs. Annu Rev Med. Solid lipid nanoparticles SLN for controlled drug delivery — a review of the state of the art. Liposomes and nanoparticles: nanosized vehicles for drug delivery in cancer. Trends Pharmacol Sci. Importance of solid lipid nanoparticles SLN in various administration routes and future perspectives. Int J Nanomedicine.
Solid lipid nanoparticles: production, characterization and applications. High payload itraconazole-incorporated lipid nanoparticles with modulated release property for oral and parenteral administration. J Pharm Pharmacol. Sustained release docetaxel-incorporated lipid nanoparticles with improved pharmacokinetics for oral and parenteral administration.
J Microencapsul. Solid lipid nanoparticles for potential doxorubicin delivery in glioblastoma treatment: preliminary in vitro studies. J Pharm Sci. Cellular uptake of solid lipid nanoparticles and cytotoxicity of encapsulated paclitaxel in A cancer cells. Int J Pharm. PEGylated solid lipid nanoparticles: design, methotrexate loading and biological evaluation in animal models.
Med Chem Commun. Characterization and evaluation of 5-fluorouracil-loaded solid lipid nanoparticles prepared via a temperature-modulated solidification technique. Nano-and micro-based inhaled drug delivery systems for targeting alveolar macrophages.
Expert Opin Drug Deliv. Current trends in the use of liposomes for tumor targeting. Torchilin VP. Recent advances with liposomes as pharmaceutical carriers. Nat Rev Drug Discov. Dendrimers and Dendrons. Concepts, Syntheses, Applications.
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Weinheim: VCH; Molecular recognition in dendrimers. In: Mark HF, editor. Encyclopedia of Polymer Science and Technology. Dendritic polymers in biomedical applications: from potential to clinical use in diagnostics and therapy.
Potential of nanoparticulate drug delivery systems by intranasal administration.
Doxorubicin delivery by polyamidoamine dendrimer conjugation and photochemical internalization for cancer therapy. J Control Release. Dendrimer-platinate: a novel approach to cancer chemotherapy.
- Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors?
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- Nanoparticulate Drug Delivery Systems - CRC Press Book.
Anticancer Drugs. In vitro release of 5-fluorouracil with cyclic core dendritic polymer. A single dose of doxorubicin-functionalized bow-tie dendrimer cures mice bearing C colon carcinomas.
Lipid Nanoparticulate Drug Delivery Systems: A Revolution in Dosage Form Design and Development
A PEGylated dendritic nanoparticulate carrier of fluorouracil. Polymer nanoparticles: preparation techniques and size-control parameters. Prog Polym Sci. Nanotechnology in therapeutics: a focus on nanoparticles as a drug delivery system.
Polymeric nanoparticles for targeted treatment in oncology: current insights. Advances of cancer therapy by nanotechnology. Cancer Res Treat. Nanoparticle-assisted combination therapies for effective cancer treatment. Ther Deliv. Nanoparticle technologies for cancer therapy. Drug Delivery. Berlin, Heidelberg: Springer Berlin Heidelberg; — Zhu Y, Liao L. Applications of nanoparticles for anticancer drug delivery: a review. J Nanosci Nanotechnol. Advanced targeted therapies in cancer: drug nanocarriers, the future of chemotherapy.
Topotecan—tamoxifen duple PLGA polymeric nanoparticles: investigation of in vitro, in vivo and cellular uptake potential. Combinatorial anticancer effects of curcumin and 5-fluorouracil loaded thiolated chitosan nanoparticles towards colon cancer treatment. Biochim Biophys Acta. Mol Pharm. Recent advances in polymeric micelles for anti-cancer drug delivery.
Eur J Pharm Sci. Polymeric micelles: recent advancements in the delivery of anticancer drugs. Pharm Res. Development of the polymer micelle carrier system for doxorubicin. Rapoport N. Physical stimuli-responsive polymeric micelles for anti-cancer drug delivery. A micelle-like structure of poloxamer—methotrexate conjugates as nanocarrier for methotrexate delivery.
Self-assembled polymeric micellar nanoparticles as nanocarriers for poorly soluble anticancer drug ethaselen. Nanoscale Res Lett. NK, a paclitaxel-incorporating micellar nanoparticle formulation, can extend in vivo antitumour activity and reduce the neurotoxicity of paclitaxel. Br J Cancer. Manchester M, Singh P.
Virus-based nanoparticles VNPs : platform technologies for diagnostic imaging.